| Primary Identifier | MGI:1923367 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 76117 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within regulation of cell shape. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain and spleen. Orthologous to human ARHGAP15 (Rho GTPase activating protein 15). PHENOTYPE: Mice homozygous for disruption of this gene display reduced leukocyte numbers and abnormally shaped macrophage. Chemotactic responses of macrophage are normal while neutrophile chemoattraction and bacterial pagocytosis are increased. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
