| Primary Identifier | MGI:1347043 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 26428 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Involved in polar body extrusion after meiotic divisions and protein polymerization. Acts upstream of or within DNA replication. Is active in cytoplasm. Is expressed in brain; embryo; and pancreas epithelium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). PHENOTYPE: Mice homozygous for a conditional allele activated in oocytes exhibit female infertility due to failure of polar body extrusion, impaired DNA synthesis, and arrested female meiosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
