| Primary Identifier | MGI:1352456 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18227 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; dopaminergic neuron differentiation; and fat cell differentiation. Acts upstream of or within several processes, including dopamine biosynthetic process; nervous system development; and regulation of primary metabolic process. Located in nucleus. Is expressed in several structures, including ear; endocrine gland; genitourinary system; integumental system; and nervous system. Used to study Parkinson's disease and schizophrenia. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2). PHENOTYPE: Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
