| Primary Identifier | MGI:102468 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18779 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phospholipase binding activity. Involved in negative regulation of phospholipase A2 activity; receptor-mediated endocytosis; and regulation of arachidonate secretion. Located in extracellular region. Is expressed in central nervous system and sensory organ. Orthologous to human PLA2R1 (phospholipase A2 receptor 1). PHENOTYPE: Homozygous null mice are viable with no overt abnormalities. These mice are more resistant to toxic effects of lipopolysaccharide than controls, suggesting a role for this gene in the progression of endotoxic shock. Mice are more prone to spontaneously develop a wide spectrum or tumors with age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
