| Primary Identifier | MGI:1918836 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 71586 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in innate immune response and response to virus. Acts upstream of or within antiviral innate immune response; protein complex oligomerization; and type I interferon-mediated signaling pathway. Located in cytoplasm. Is expressed in brain and embryo. Used to study Aicardi-Goutieres syndrome and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human IFIH1 (interferon induced with helicase C domain 1). PHENOTYPE: Mice homozygous for a null allele have increased virus-associated morbidity and mortality, and decreased cytokine response to several viral infections. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
