Primary Identifier | MGI:1890647 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 60344 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Acts upstream of or within locomotory behavior. Located in nuclear matrix. Is expressed in central nervous system and heart. Orthologous to human FIGN (fidgetin, microtubule severing factor). PHENOTYPE: Homozygotes for a reporter allele show pre- and postnatal death, head-shaking, and small eyes. Spontaneous mutants show head-shaking, circling, reduced or absent semicircular canals, small abnormal eyes, aberrant cell-cycling, female sterility, and low prenetrance craniofacial and skeletal defects. [provided by MGI curators] |