| Primary Identifier | MGI:1355324 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 50915 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-macromolecule adaptor activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to act upstream of or within signal transduction. Predicted to be located in endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in forebrain; ganglia; male reproductive gland or organ; and nucleus pulposus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GRB14 (growth factor receptor bound protein 14). PHENOTYPE: Homozygous mutation of this gene results in improved glucose tolerance, lower circulating insulin levels and increased incorporation of glucose into glycogen in the liver and skeletal muscle of males. Both males and females exhibit a decrease in body size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
