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Protein Coding Gene : Dcaf17 DDB1 and CUL4 associated factor 17
Primary Identifier  MGI:1923013 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  75763
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within acrosome assembly and cell morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including gut; lower urinary tract; nasal cavity epithelium; submandibular gland primordium; and ventral grey horn. Human ortholog(s) of this gene implicated in Woodhouse-Sakati syndrome. Orthologous to human DCAF17 (DDB1 and CUL4 associated factor 17).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with defects in spermatogenesis. [provided by MGI curators]
  • synonyms:
  • 4833418A01Rik,
  • expressed sequence AI448937,
  • RIKEN cDNA 4833418A01 gene,
  • A930009G19Rik,
  • A030004A10Rik,
  • AI448937,
  • MGI:2138954,
  • Dcaf17,
  • RIKEN cDNA A930009G19 gene,
  • RIKEN cDNA 2810055O12 gene,
  • MGI:1919978,
  • MGI:3028055,
  • DDB1 and CUL4 associated factor 17,
  • RIKEN cDNA A030004A10 gene,
  • MGI:1925539,
  • 2810055O12Rik
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