| Primary Identifier | MGI:109349 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 11909 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including growth plate cartilage development; hindbrain development; and intracellular signal transduction. Acts upstream of or within with a positive effect on cellular response to leucine starvation and regulation of transcription by RNA polymerase II. Acts upstream of or within adipose tissue development; outflow tract morphogenesis; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). PHENOTYPE: Homozygous mutation of this gene results in increased postnatal lethality, skeletal development defects, runting, decreased hearing, inner ear and brain abnormalities, hyperactivity, and ataxia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
