Primary Identifier | MGI:1916732 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 69482 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus and plasma membrane. Predicted to be part of nuclear pore central transport channel and nuclear pore nuclear basket. Is expressed in cerebellum. Used to study intestinal pseudo-obstruction. Orthologous to human NUP35 (nucleoporin 35). PHENOTYPE: Homozygous knockout through a point mutation in a critical functional domain leads to early death as a result of megacolon caused by colon myopathy. [provided by MGI curators] |