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Protein Coding Gene : Btbd18 BTB domain containing 18
Primary Identifier  MGI:3650217 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  100270744
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in male meiosis I; piRNA transcription; and spermatogenesis. Acts upstream of with a positive effect on transposable element silencing. Located in nucleus. Is expressed in several structures, including diencephalon; genitourinary system; gut; liver; and spleen. Orthologous to human BTBD18 (BTB domain containing 18).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased male germ cell apoptosis and arrested spermiogenesis resulting in azoospermia and male infertility. [provided by MGI curators]
  • synonyms:
  • OTTMUSG00000013494,
  • Gm13718,
  • BTB domain containing 18,
  • Btbd18-ps,
  • predicted gene, OTTMUSG00000013494,
  • predicted gene 13718,
  • BTB (POZ) domain containing 18, pseudogene,
  • Btbd18
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4 Involved In Mutations

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