Primary Identifier | MGI:1923573 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 228136 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables palmitoyltransferase activity. Involved in positive regulation of defense response and positive regulation of protein localization. Acts upstream of or within protein palmitoylation. Located in dendrite; phagocytic vesicle; and plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in early conceptus; eye; heart; oocyte; and trunk somite. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5). PHENOTYPE: Mice homozygous for a hypomorphic allele exhibit partial prenatal lethality and impaired contextual conditioning. Mice homozygous for a conditional allele activated in adipocytes exhibit impaired fatty acid uptake and impairedadaptive thermogenesis. [provided by MGI curators] |