| Primary Identifier | MGI:894696 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 12258 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway and negative regulation of endopeptidase activity. Located in extracellular space. Is expressed in several structures, including cerebral cortex; genitourinary system; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). PHENOTYPE: Mutant mice exhibit an increased vascular permeability compared to controls. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
