| Primary Identifier | MGI:104574 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 19271 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein tyrosine phosphatase activity. Involved in several processes, including regulation of cell migration; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). PHENOTYPE: Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
