Primary Identifier | MGI:1914695 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 67445 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via STAT; protein phosphorylation; and reduction of food intake in response to dietary excess. Predicted to be active in extracellular space. Is expressed in brain and retina. Orthologous to human C1QTNF4 (C1q and TNF related 4). PHENOTYPE: Male mice homozygous for a mutation are viable and show normal fertility. Mice homozygous for a null allele exhibit increased sensitivity to LPS treatment with increased mortality. [provided by MGI curators] |