| Primary Identifier | MGI:98282 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 20375 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and histone deacetylase binding activity. Involved in several processes, including lymphocyte differentiation; regulation of macromolecule biosynthetic process; and regulation of myeloid leukocyte mediated immunity. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; hemopoiesis; and regulation of DNA-templated transcription. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene). PHENOTYPE: Nullizygous mice may exhibit fetal or perinatal lethality, absence of myeloid and B cells, and altered T cell and NK cell development. Mice carrying hypomorphic alleles display impaired B-cell and myeloid development, develop T cell derived lymphomas andacute myeloid leukemia, and die prematurely. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
