| Primary Identifier | MGI:1355314 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 107986 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to contribute to damaged DNA binding activity and ubiquitin-protein transferase activity. Involved in DNA damage response and cellular response to UV. Acts upstream of or within pyrimidine dimer repair. Part of Cul4A-RING E3 ubiquitin ligase complex. Used to study xeroderma pigmentosum group E. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group E. Orthologous to human DDB2 (damage specific DNA binding protein 2). PHENOTYPE: Mutant mice are prone to both spontaneous and UV-induced skin cancer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
