Primary Identifier | MGI:2445003 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 228359 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activator activity. Predicted to be involved in several processes, including negative regulation of endocytic recycling; small GTPase-mediated signal transduction; and transferrin transport. Located in plasma membrane and ruffle. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). PHENOTYPE: Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation. [provided by MGI curators] |