Primary Identifier | MGI:1270859 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 12953 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including FAD binding activity; nuclear receptor binding activity; and protein kinase binding activity. Involved in several processes, including entrainment of circadian clock by photoperiod; negative regulation of cell communication; and regulation of gene expression. Acts upstream of or within protein import into nucleus. Located in mitochondrion and nucleus. Part of Cry-Per complex. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; reproductive system; and sensory organ. Orthologous to human CRY2 (cryptochrome circadian regulator 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure. [provided by MGI curators] |