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Protein Coding Gene : Ano3 anoctamin 3
Primary Identifier  MGI:3613666 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  228432
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables phospholipid scramblase activity. Acts upstream of or within calcium activated galactosylceramide scrambling; calcium activated phosphatidylcholine scrambling; and establishment of localization in cell. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; apical ectodermal ridge; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in dystonia 24. Orthologous to human ANO3 (anoctamin 3).
PHENOTYPE: Mice with brain-specific or Ptgds-expressing cell knock-out display greater susceptibility of hyperthermia-induced seizures and deficiency in thermoregulation. [provided by MGI curators]
  • synonyms:
  • MGI:3045304,
  • MGI:2139060,
  • AI838058,
  • anoctamin 3,
  • Tmem16c,
  • transmembrane protein 16C,
  • B230324K02Rik,
  • expressed sequence AI838058,
  • RIKEN cDNA B230324K02 gene,
  • Ano3
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Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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