| Primary Identifier | MGI:1344337 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 23892 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including circulatory system development; nephron epithelium morphogenesis; and regulation of primary metabolic process. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). PHENOTYPE: Homozygous null mice display neonatal lethality with bilateral agenesis of the kidneys and ureters, oligodactyly, limb skeletal malformations, cyanosis, dyspnea, and abnormal lung morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
