Primary Identifier | MGI:97890 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 19361 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA strand exchange activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; cellular response to hydroxyurea; and chromosome organization. Located in chromosome; cytoplasm; and male germ cell nucleus. Is active in site of double-strand break. Is expressed in several structures, including brain; compacted morula; gonad; hemolymphoid system; and paravertebral ganglion. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). PHENOTYPE: Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage. [provided by MGI curators] |