| Primary Identifier | MGI:1915392 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 68142 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP hydrolysis activity; alpha-tubulin binding activity; and histone binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in cytosol and nuclear body. Predicted to be part of Ino80 complex. Is expressed in several structures, including ectoderm; genitourinary system; liver; muscle tissue; and primitive endoderm. Orthologous to human INO80 (INO80 complex ATPase subunit). PHENOTYPE: Embryos homozygous for a knock-out allele die around E7.5 and show absence of anterior and distal visceral endoderm. Another null allele results in embryonic lethality by E13.5-E14.5 with severe growth retardation and developmental defects. Heterozygotes show defects in hindlimb extension reflex. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
