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Protein Coding Gene : Itpka inositol 1,4,5-trisphosphate 3-kinase A
Primary Identifier  MGI:1333822 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  228550
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable calcium/calmodulin-dependent protein kinase activity; inositol phosphate kinase activity; and small GTPase binding activity. Acts upstream of or within inositol metabolic process and regulation of synaptic plasticity. Predicted to be located in cytoskeleton and dendritic spine. Predicted to be active in several cellular components, including glutamatergic synapse; nucleus; and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A).
PHENOTYPE: Mice homozygous for a knock-out allele display enhanced long term potentiation in the hippocampal CA1 region. [provided by MGI curators]
  • synonyms:
  • IP3-kinase A,
  • Itpka,
  • inositol 1,4,5-trisphosphate 3-kinase A,
  • MGC:28924
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Features --> Cross References

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0 Canonical

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2 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

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Disease

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