Primary Identifier | MGI:1914828 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 67578 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity and translation repressor activity. Acts upstream of or within negative regulation of cytoplasmic mRNA processing body assembly. Located in P-body and nucleus. Used to study ovarian disease. Orthologous to human PATL2 (PAT1 homolog 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit defects in oocyte maturation, abnormal female meiosis I arrest, reduced female fertility, and impaired fertilization affecting preimplantation embryo development. Male fertility is normal. [provided by MGI curators] |