| Primary Identifier | MGI:2384861 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 213696 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable enzyme binding activity. Acts upstream of or within several processes, including hydrogen peroxide metabolic process; positive regulation of reactive oxygen species metabolic process; and regulation of thyroid hormone generation. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; skeletal muscle; and spleen. Orthologous to human DUOXA1 (dual oxidase maturation factor 1). PHENOTYPE: Mice homozygous for a knock-out allele of Duoxa1 and 2 exhibit severe hypothyrodism with severe postnatal growth, delayed eye opening, enlarged thyroid, enlarged adenohypophysis, respiratory distress and death at weaning when weaned at 21 days. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
