| Primary Identifier | MGI:95521 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 14178 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of DNA-templated transcription and regulation of synapse maturation. Acts upstream of or within morphogenesis of an epithelium; positive regulation of cell population proliferation; and regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in Golgi apparatus and extracellular region. Is active in GABA-ergic synapse and postsynapse. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human FGF7 (fibroblast growth factor 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal coat appearance, kidney dysplasia, spleen hypoplasia, abnormal synaptic vesicle clustering and miniature inhibitory postsynaptic currents, increased susceptibility to drug-induced seizures, and impaired thymic recovery after injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
