| Primary Identifier | MGI:96062 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 15186 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histidine decarboxylase activity. Acts upstream of or within L-histidine catabolic process and histamine biosynthetic process. Predicted to be located in dendrite and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal mast cells, altered anxiety-related and nociceptive behavior, altered cognitive function, increased weight gain, visceral adiposity, increased amount of brown adipose tissue, impaired glucose tolerance, hyperinsulinemia, and hyperleptinemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
