| Primary Identifier | MGI:1929996 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 58800 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytoskeletal protein binding activity; metal ion transmembrane transporter activity; and protein kinase activity. Involved in intracellular magnesium ion homeostasis; metal ion transport; and protein homotetramerization. Acts upstream of or within several processes, including actomyosin structure organization; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in several cellular components, including cytoplasmic vesicle; nucleus; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). PHENOTYPE: Mice homozygous for a null allele display embryonic lehality. Mice with conditional deletion in developing thymocytes display a block in thymopoiesis. Mice homozygous for a kinase deleted allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit altered magnesium homeostasis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
