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Protein Coding Gene : Tmem127 transmembrane protein 127
Primary Identifier  MGI:1916720 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  69470
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable small GTPase binding activity. Acts upstream of or within endosome organization and regulation of TOR signaling. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Is expressed in medulla oblongata basal plate and ventral grey horn. Human ortholog(s) of this gene implicated in pheochromocytoma. Orthologous to human TMEM127 (transmembrane protein 127).
PHENOTYPE: Lysosomal activity and endosomal fusion mediated by Rab5 were affected in mouse embryonic fibroblasts of homozygous null mutants [provided by MGI curators]
  • synonyms:
  • transmembrane protein 127,
  • 2310003P10Rik,
  • RIKEN cDNA 2310003P10 gene,
  • expressed sequence AI314202,
  • MGI:2138878,
  • AI317350,
  • AI314202,
  • MGI:2138898,
  • expressed sequence AI317350,
  • Tmem127
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Features --> Cross References

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2 Involved In Mutations

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