Primary Identifier | MGI:101911 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 13537 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human DUSP2 (dual specificity phosphatase 2). PHENOTYPE: Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis. [provided by MGI curators] |