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Protein Coding Gene : Ttl tubulin tyrosine ligase
Primary Identifier  MGI:1916987 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  69737
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables tubulin-tyrosine ligase activity. Acts upstream of or within microtubule cytoskeleton organization and regulation of axon extension. Predicted to be located in microtubule. Predicted to be active in spindle microtubule. Is expressed in musculature and nervous system. Orthologous to human TTL (tubulin tyrosine ligase).
PHENOTYPE: Homozygous null mice display neonatal lethality, impaired breathing, and fail to form the internal capsule in the brain. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2700049H19 gene,
  • MGI:2139074,
  • 2700049H19Rik,
  • tubulin tyrosine ligase,
  • Ttl,
  • 2410003M22Rik,
  • RIKEN cDNA 2410003M22 gene,
  • MGI:1922085,
  • AI848570,
  • expressed sequence AI848570
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2 Involved In Mutations

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Disease

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