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Protein Coding Gene : Ttl tubulin tyrosine ligase
Primary Identifier  MGI:1916987 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  69737
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables tubulin-tyrosine ligase activity. Acts upstream of or within microtubule cytoskeleton organization and regulation of axon extension. Predicted to be located in microtubule. Predicted to be active in spindle microtubule. Is expressed in musculature and nervous system. Orthologous to human TTL (tubulin tyrosine ligase).
PHENOTYPE: Homozygous null mice display neonatal lethality, impaired breathing, and fail to form the internal capsule in the brain. [provided by MGI curators]
  • synonyms:
  • 2410003M22Rik,
  • RIKEN cDNA 2700049H19 gene,
  • 2700049H19Rik,
  • RIKEN cDNA 2410003M22 gene,
  • tubulin tyrosine ligase,
  • MGI:2139074,
  • MGI:1922085,
  • AI848570,
  • Ttl,
  • expressed sequence AI848570
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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