| Primary Identifier | MGI:97808 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 19262 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein tyrosine phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse and synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; extraembryonic component; future brain; and genitourinary system. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). PHENOTYPE: Homozygotes for a targeted null mutation exhibit deficits in Morris water maze learning, reduced locomotor activity, and decreased anxiety. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
