| Primary Identifier | MGI:2181363 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 246313 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor activity. Acts upstream of or within circadian rhythm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; hemolymphoid system gland; nose; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). PHENOTYPE: Homozygotes for a null allele show 50% neonatal lethality, olfactory bulb malformation, and reproductive system atrophy related to a lack of hypothalamic gonadotropin-releasing hormone synthesizing neurons. Homozygotes for another null allele show impaired circadian behavior and thermoregulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
