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Protein Coding Gene : Ism1 isthmin 1, angiogenesis inhibitor
Primary Identifier  MGI:2442963 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  319909
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in negative regulation of angiogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including brain; eye; immune system; limb long bone; and lung. Orthologous to human ISM1 (isthmin 1).
PHENOTYPE: Homozygous knockout results in impaired glucose tolerance caused by reduced glucose uptake by brown adipose tissue and skeletal muscle. Overexpression reduces de novo lipogenesis and promotes protein synthesis in hepatocytes. [provided by MGI curators]
  • synonyms:
  • expressed sequence AV354986,
  • RIKEN cDNA 5430433G21 gene,
  • 5430433G21Rik,
  • isthmin 1, angiogenesis inhibitor,
  • MGI:2139269,
  • Ism1,
  • AV354986
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2 Involved In Mutations

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