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Protein Coding Gene : Dstn destrin
Primary Identifier  MGI:1929270 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  56431
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables actin filament binding activity. Involved in actin filament fragmentation. Acts upstream of or within cell motility and positive regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and skin. Orthologous to human DSTN (destrin, actin depolymerizing factor).
PHENOTYPE: Mice carrying mutations at this locus develop irregular thickening of the corneal epithelium. [provided by MGI curators]
  • synonyms:
  • Dstn,
  • corn1,
  • expressed sequence AU042046,
  • corneal disease 1,
  • MGD-MRK-33921,
  • MGI:1917157,
  • RIKEN cDNA 2610043P17 gene,
  • MGI:2139214,
  • ADF,
  • AU042046,
  • sid23p,
  • MGI:106229,
  • 2610043P17Rik,
  • destrin
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