Primary Identifier | MGI:1917264 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 228714 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in nucleus. Part of ATAC complex. Is expressed in embryo and extraembryonic component. Orthologous to human KAT14 (lysine acetyltransferase 14). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, decreased size, increased apoptosis, and disrupted cell cycling. Mice heterozygous for one targeted allele exhibit corneal opacity. [provided by MGI curators] |