Primary Identifier | MGI:2137513 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 94249 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium, potassium:sodium antiporter activity. Acts upstream of or within bone mineralization; intracellular calcium ion homeostasis; and regulation of gene expression. Located in cell periphery. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; eye; and musculature. Orthologous to human SLC24A3 (solute carrier family 24 member 3). PHENOTYPE: Null mice show reduced bone mineral content, density and bone strength, thinner compact bone, increased parathyroid hormone level, shorter duodenum villus length, increased severity of induced colitis, increased depression-related behavior, and motor learning and sociability deficits. [provided by MGI curators] |