Primary Identifier | MGI:3036245 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 241694 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory cortex mantle layer; and olfactory epithelium. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators] |