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Protein Coding Gene : Cst8 cystatin 8 (cystatin-related epididymal spermatogenic)
Primary Identifier  MGI:107161 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  13012
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable cysteine-type endopeptidase inhibitor activity. Located in cell surface; cytoplasm; and extracellular region. Is expressed in epididymis; gonad; and urogenital ridge. Orthologous to human CST8 (cystatin 8).
PHENOTYPE: Mice homozygous for a knock-out allele are fertile although males show a small reduction in total and progressive sperm motility, oligozoospermia, and decreased in vitro sperm fertilizing ability associated with impaired sperm capacitation and acrosome reaction. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-2208,
  • Cst-rs1,
  • cystatin related epididymal specific,
  • Cres,
  • MGD-MRK-35622,
  • cystatin related sequence 1, epididymal,
  • cystatin 8 (cystatin-related epididymal spermatogenic),
  • Cst8
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