Primary Identifier | MGI:1345675 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 228775 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of fat cell differentiation; and regulation of protein modification process. Located in nucleus. Is expressed in several structures, including bone; central nervous system; genitourinary system; heart; and retina. Orthologous to human TRIB3 (tribbles pseudokinase 3). PHENOTYPE: Homozygous null mutants may display hypoactivity, decreased blood pressure and abnormal digit morphology or abnormal mast cell physiology. [provided by MGI curators] |