| Primary Identifier | MGI:88139 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 12048 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including BH3 domain binding activity; MDM2/MDM4 family protein binding activity; and enzyme binding activity. Acts upstream of or within several processes, including apoptotic signaling pathway; gonad development; and negative regulation of apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; inner ear; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1). PHENOTYPE: Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
