| Primary Identifier | MGI:3649996 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 668932 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates. Involved in transposable element silencing by piRNA-mediated DNA methylation and transposable element silencing by piRNA-mediated heterochromatin formation. Acts upstream of or within gene silencing by piRNA-directed DNA methylation; homologous chromosome pairing at meiosis; and transposable element silencing by heterochromatin formation. Located in nucleus. PHENOTYPE: Mice homozygous for an ENU or endonuclease-mediated mutation alleles exhibit reduced transposon and retrotransposons in male germ cells, male infertility, meiotic arrest, azoospermia and hypogonadism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
