| Primary Identifier | MGI:87853 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 50518 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables type 3 melanocortin receptor binding activity and type 4 melanocortin receptor binding activity. Involved in melanin biosynthetic process and positive regulation of melanin biosynthetic process. Acts upstream of or within several processes, including adult feeding behavior; melanosome organization; and melanosome transport. Predicted to be active in extracellular space. Is expressed in forelimb epithelium; hair bulb; hindlimb epithelium; and skin. Used to study abdominal obesity-metabolic syndrome 1; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in pigmentation disease. Orthologous to human ASIP (agouti signaling protein). PHENOTYPE: Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
