| Primary Identifier | MGI:3710243 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 668940 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in regulation of CAMKK-AMPK signaling cascade; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Located in cardiac myofibril. Is expressed in several structures, including autopod; embryo mesenchyme; heart; lens; and musculature. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). PHENOTYPE: Homozygous knockout does not affect heart development, but exogenous expression in cardiomyocytes leads to increased atrial and ventricular weights, left ventricular dilation and decreased fractional shortening. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
