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Protein Coding Gene : Procr protein C receptor, endothelial
Primary Identifier  MGI:104596 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  19124
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of coagulation. Located in centrosome. Is expressed in several structures, including cardiovascular system; extraembryonic component; liver; placenta; and vasculature of uterus. Orthologous to human PROCR (protein C receptor).
PHENOTYPE: Nullizygous embryos die by E10.5 showing placental thrombosis, small size, and incomplete turning. Mice with a severe deficiency survive and reproduce normally. Homozygotes for the R84A variant show increased thrombin formation after thrombotic and LPS challenge, splenomegaly, and bone marrow failure. [provided by MGI curators]
  • synonyms:
  • Procr,
  • MGD-MRK-24087,
  • Ccca,
  • AI325044,
  • expressed sequence AI325044,
  • EPCR,
  • cell cycle, dependent gene, centrosome-associated,
  • MGI:2138904,
  • protein C receptor, endothelial,
  • MGD-MRK-26030
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1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

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Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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