Primary Identifier | MGI:2444120 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 245865 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in microtubule. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Is expressed in brainstem; genitourinary system; submandibular gland; and trachea. Orthologous to human SPAG4 (sperm associated antigen 4). PHENOTYPE: Mice homozygous for a knock-out allele show disrupted spermiogenesis, severe defects in sperm head formation, abnormal manchette morphology, globozoospermia, and male infertility. [provided by MGI curators] |