Primary Identifier | MGI:2138865 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 228836 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable molecular adaptor activity and protein domain specific binding activity. Involved in modification of postsynaptic structure and regulation of synapse maturation. Located in synapse. Is active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. Is expressed in nervous system and neural retina. Used to study autism spectrum disorder. Orthologous to human DLGAP4 (DLG associated protein 4). PHENOTYPE: Mice homozygous for a null allele display impaired dendrite morphology, increased mean postsynaptic density area, and impaired vocal communication and social interaction. [provided by MGI curators] |