| Primary Identifier | MGI:95709 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 14601 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables growth hormone-releasing hormone receptor binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including adenohypophysis development; growth hormone secretion; and response to food. Located in extracellular space and terminal bouton. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; integumental system; and reproductive system. Used to study isolated growth hormone deficiency type IA. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Orthologous to human GHRH (growth hormone releasing hormone). PHENOTYPE: Mice homozygoous for a knock-out allele exhibit postnatal growth retardation, decreased body weight and body length, reduced IGF-I production and serum IGF-I levels, pituitary hypoplasia, decreased growth hormone level, and decreased litter size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
